Sabinsa has been granted a patent in Mexico for a combination of ingredients touted for protecting hair. The mix is made of proprietary ingredients derived from amla, coconut water and selenopeptides. It is positioned to protect the dermal papilla cells from UV-induced damage, thereby maintaining them in numbers conducive to hair growth.
A clinical study backs the patent in Mexico, expanding Sabinsa’s footprint of hair-promoting ingredient patents.
“Preparations to stimulate hair growth are in high demand and it’s past time for there to be a natural alternative in this category,” says Dr. Muhammed Majeed, founder and chairman of Sabinsa.
The recent patent MX355546 is for a composition comprising 10 percent w/w of 1-0-galloyl-β-D-glucose (β-glucogallin), specifically isolated from Emblica officinalis (Saberry) and a concentrate from the liquid endosperm of Cocos nucifera (Cococin) along with selenopeptides for protecting the dermal papilla cells.
Patents for the ingredients have also been granted in Canada, Japan, Russia, Europe, Indonesia, Malaysia, Australia, New Zealand, the US and Hong Kong.
The ingredient combination was shown to significantly reduce hair fall and thinning in the human clinical study.
For 90 days, 42 healthy men and women supplemented with a serum containing Saberry amla extract, Cococin freeze-dried coconut water and PeptiSeLect selenium.
After the trial, participants who continued supplementation experienced a 57 percent reduction in hair breakage and 81 percent reduction in hair fall.
Moreover, all subjects reported an overall improvement in hair texture and hair volume with reduced hair fall. Scalp conditions noted during the baseline visits, including itching, dryness and dandruff, were resolved after applying the product.
Protecting dermal papilla
Dermal papilla cells are specialized mesenchymal cells that exist at the bottom of hair follicles. These cells play pivotal roles in hair formation, growth and cycling, notes the company.
Maintaining a sufficient number of dermal papillae, which are vulnerable to a wide range of environmental factors, is essential for hair growth.
Dermal papilla cells accumulate below undifferentiated epidermis, which is then stimulated to grow down into the dermis as a hair “peg.” Interaction between the hair peg and the dermal papilla cells promotes differentiation into a mature hair follicle.
The open-label clinical trial evaluated the efficacy and safety of Sabinsa’s hair serum in healthy adult male and female subjects.
The results found that the synergistic combination maintained the number of live dermal papilla cells at a level of 95 percent or more when the dermal papilla cells are exposed to UVB radiation levels in the range of from 0.8 J/cm² to 1.0J/cm².
The clinical study was published in Clinical, Cosmetic and Investigational Dermatology.
This month Sabinsa also published new research on its LactoSporin postbiotics, which was found to have antimicrobial activity against various pathogenic bacteria, including Cutibacterium acnes. The study concluded that LactoSporin is suitable for treating subjects with mild-to-moderate acne vulgaris.
Fonte: Nutrition Insight